Abstract
SIMULTANEOUS SPECTROPHOTOMETRIC DETERMINATION OF FEBUXOSTAT AND DICLOFENAC IN PHARMACEUTICAL DOSAGE USING CHEMOMETRIC METHODS

Ibrahim H.I. Habib, Mohamed Rizk, Maha Mahmoud Abou El-Alamin, Ghada Sayed Imam*

ABSTRACT

Simultaneous spectrophotometric determination of Febuxostat (FEB) and Diclofenac potassium (DIC) in pharmaceutical dosage using four different chemometric techniques, Iterative Target Transformation Factor Analysis (ITTFA), Classical Least Squares (CLS), Principal Component Regression (PCR) and Partial Least- Squares (PLS-1). In these techniques, the concentration data matrix was prepared according to the full factorial experimental design of three levels and two components in mixtures and using 2.5 mM NaOH solution as solvent. The corresponding absorbance data matrix was measured over the wavelength range of 220 - 400 nm with the intervals of Δλ= 1 nm, then regression was obtained by using the concentration data matrix and absorbance data matrix for the prediction of the unknown concentrations of FEB and DIC in their mixture. The procedure did not require any chemical separation step or prior graphical treatment of the overlapped spectra. The calibration range was found linear over 2-10 and 2.5-25 μg/mL for FEB and DIC, respectively and the multivariate methods were validated on both authentic mixtures and pharmaceutical preparations. The precision and accuracy of the methods were assessed and compared with each other.

Keywords: Febuxostat, Diclofenac potassium, Iterative Target Transformation Factor Analysis, Classical Least Squares, Principal Component Regression, Partial Least-Squares.


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