European Journal of Biomedical and Pharmaceutical Sciences

IMPORTANCE OF AUTOTAXIN IN LIVER DISORDERS AND INTERACTION WITH OTHER LIPID MEDIATORS AND POSSIBLY NATRIURETIC PEPTIDES

Manoj G. Tyagi*

ABSTRACT

Natriuretic peptides and in particular the B-type natriuretic peptide (BNP) stimulates the proliferation, differentiation, and lipolysis of preadipocytes by upregulation of the levels of expression of its receptor NPR1 and key genes enriched in the glycerolipid metabolic pathway. These lipids accumulate in the liver. Recent studies suggest that BNP may stimulate lipid metabolism by affecting various enzymes. On the other hand, Lysophosphatidic acid (LPA) is a bioactive lipid mediator involved in many biological processes. Concentrations of the major LPA species in mouse plasma decrease following administration of a potent selective inhibitor of the LPA-generating lysophospholipase D (autotaxin) identifying an active mechanism for removal of LPA from the circulation. This review examines the effect of Autotaxin in liver disorders and possible implications for the involvement of natriuretic peptides in the lipid metabolism in liver.

Keywords: B-type natriuretic peptide, Liver, Lipids, Lysophosphatidic acid, Autotaxin.