European Journal of Biomedical and Pharmaceutical Sciences

NOVEL APROACHES - MUCOADHESIVE BUCCAL DRUG DELIVERY SYSTEM

Suhel Khan*, Nayyar Parvez, Pramod Kumar Sharma, Md. Aftab Alam and Musarrat Husain Warsi

ABSTRACT

Among novel drug delivery systems, Buccal mucoadhesive systems have attracted great attention in recent years due to their ability to adhere and remain on the oral mucosa and to release their drug content gradually. Mucoadhesion may be defined as the process where polymers attach to biological substrate or a synthetic or natural macromolecule, to mucus or an epithelial surface. Buccal mucoadhesive films can improve the therapeutic effect of drug by increasing the absorption of drug through oral mucosa which increases the drug bioavailability by reducing the hepatic first pass effect. Natural polymers have recently gained importance in pharmaceutical field. Mucoadhesive polymers are used to improve drug delivery by increasing the dosage form’s contact time and residence time with the mucous membranes. This review article deals with the novel approaches use in the buccal drug delivery systems.

Keywords: Buccal delivery, permeation enhancers, Mucoadhesive, chitosan, Bioadhesive strength.