A PROSPECTIVE OBSERVATIONAL STUDY ON ASSESMENT OF NEPHROTOXICITY DUE TO USAGE OF CEFTRIAXONE AND AMIKACIN
C. Sugunakar Raju*, R. Siddarama, Shaik Kaleemulla, M. Janardhan, M. Venkata Subbaiah, Dr. M. Madan Mohan Rao
ABSTRACT
Aim: This study sought to investigate or assessing the nephrotoxicity in patients who are administered ceftriaxone
and amikacin more than 7 days. Design: A prospective observational study. Methods: All patients receiving
ceftriaxone and amikacin were monitored and evaluated over 3 months. Patients who are administered in hospital
receiving ceftriaxone and amikacin more than 7 days are recruited. Those patients are requested to undergo renal
function test [BUN, SrCr] for assessment of kidney functioning test[RFT]. Based on the Renal function test
percentage of occurring nephrotoxicity in those patients can be identified. Results: Result showed that amikacin
and ceftriaxone-treated patients experienced a rise in the serum creatinine level and BUN that fit the designated
definition of nephrotoxicity-i.e., an increase to at least 60 percent. Conclusion: Nephrotoxicity due to amikacin
and ceftriaxone are confirmed in this present study. Therefore patients under antibiotic therapy, treatment must be
done cautiously further in depth long term study is required for proving more information aimed to safer
therapeutics, specially for antibiotics.
Keywords: Ceftriaxone, Amikacin, Nephrotoxicity, BUN, Serum creatinine.
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