Abstract
COMPARATIVE EVALUATION OF THE CYTOTOXICITY OF BIODENTINE CEMENT MIXED WITH A NEW POTENTIAL REGENERATIVE SCAFFOLD HYDROGEL TO PERIODONTAL LIGAMENT FIBROBLAST CELLS.

Dr. Malini Shankar*, Dr. Preeti Dodwad, Dr. Kishore Bhatt, Dr. Nikhil Jambagi, Dr. Ravindra Singh
Shekhawat, Dr. Niraj Godbole

ABSTRACT

Aim of the study: To investigate the cytotoxicity of Biodentine (Septodont, France) cement mixed with a new potential regenerative scaffold hydrogel (Placentrex) to periodontal ligament (PDL) fibroblast cells. Methodology: Periodontal ligament fibroblast cells were seeded into 24 well plates containing Biodentine (Group1), placentrex (Group 2), Biodentine coated with placentrex (Group 3) and Biodentine mixed with Placentrex gel (Group 4) respectively, in 6 wells each for 7 days by changing the growth medium every other day. On the 3rd day, and 7th day, the cell viability and proliferation of the cells was assayed using the MTT assay test and the absorbance reading at 490nm was recorded in an ELISA plate reader. Results and Conclusion: Within the limitations of the present study, Both Biodentine and Placentrex are highly biocompatible materials Biodentine coated with Placentrex gel was least cytotoxic and showed increased proliferation of cells. The use of Placentrex gel as an injectable scaffold has immense potential in regenerative procedures.

Keywords: Biodentine cement, Placentrex gel, cytotoxicity.


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