P. Eswaramma*, M. Vijayakumari, T. Anuradha, A. G. Ashok Kumar, B. Lakshminarayana, D. Haseena Begam and S. K. Moulana


The objective of the current study was to develop and evaluate fast disintegrating tablets of Rosiglitazone which is an effective drug in the treatment of type II diabetes mellitus. Rosiglitazone containing tablets were prepared by direct compression method using different ingredients such as Cros carmellose sodium,Crospovidone, Sodium starch glycolate , Mannitol, aspartame, Magnesium stearate. The tablets were evaluated for physical properties including Hardness, Weight variation, Thickness, Friability, Drug content, Wetting time, In-vitro disintegration time, In-vitro dissolution study and also Drug release kinetic study. The Hardness, Weight variation, Thickness, Friability and Drug content of tablets were found to be acceptable according to pharmacopoeial limits. An optimized tablet formulation i.e. F6 was found, which provided short wetting time of 54 sec, In-vitro disintegration time of 29 sec. From the above results, it indicated that the amount of superdisintegrant i.e. crospovidone was significantly affected the dependent variables like wetting time and In-vitro disintegration time. The best in-vitro drug release was found to be in formulation F6 i.e.99.18% during the end of 10 min.Formulations were subjected to stability studies , Formulations are stable for 45days at different temperatures i.e 4o C, 27oC and 40 oC / 75 % RH with insignificant change in the hardness, disintegration time and in vitro drug release pattern. All the formulations i.e. F1 to F9 followed the first order release kinetics with diffusion mechanism.

Keywords: Fast Disintegrating Tablet, Rosiglitazone, Superdisintegrants, Crospovidone.

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