MICROENCAPSULATED CIPROFLOXACIN HYDROCHLORIDE AUGMENTED DRUG DELIVERY AND ANTIBACTERIAL ACTIVITY AGAINST PATHOGENIC E.COLI STRAIN
Sangeeta Sharma and Dinesh Kaushik*
ABSTRACT
Ciprofloxacin is a second generation fluoroquinolone having fluorine at position 6 of the quinolone ring having a
good activity against most strains of bacterial pathogens responsible for respiratory, urinary tract,
gastrointestinal, and abdominal infections, including Gram (-) (Escherichia coli, Haemophillus influenza,
Klebsiella pneumonia, Proteus mirabilis), and Gram(+) (methicillin-sensitive but not methicillin-resistant
Streptococcus pneumonia, Staphyloccccusepidermidis, Enterococcus faecalis, and Streptococcus pyrogens)
bacterial pathogens.[1] Ciprofloxacin is valued for its broad spectrum of activity, its excellent tissue penetration &
for their availability in both oral and intravenous formulations. Moreover, ciprofloxacin is used alone or in
combination with other antibacterial drugs in the empiric treatment of infections for which for which bacterial
pathogen has not identified, including urinary tract infections and abdominal infections &infection caused by
specific pathogen known to be sensitive.[2-5] It kills bacteria by interfering with the enzymes that cause DNA to
rewind after being copied, which stops synthesis of DNA and other enzymes. However, due to drug resistance and
limited access to bacteria, there is urgent need to develop modified drug delivery systems of ciprofloxacin with
desired release profile as well as antibacterial activity. Therefore, in present investigation, gelatine microspheres of
ciprofloxacin were prepared by coacervation method. Subsequently, these microspheres were analyzed by using
spectral and biological techniques.
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