Abstract
MATERNAL THYROID PROFILE PATTERNS IN THE THREE TRIMESTERS OF HEALTHY PREGNANT WOMEN IN JODHPUR DISTRICT OF RAJASTHAN

Umar Abdullahi Zakariyya*, Deepa Singh, Abdullahi Sulaiman, Nura Audu, Jamila A. Mashi, Mahmud Abdullahi Ginya

ABSTRACT

Pregnancy is associated with significant but reversible changes in thyroid function tests results, which are among the most profound seen as a result of a normal physiologic state. During pregnancy the thyroid is hyperstimulated, resulting in changes in thyroid hormone concentrations. Accurate assessment of thyroid function during pregnancy is critical, for both the initiation of thyroid hormone therapy, adjustment of thyroid hormone dose in those already receiving thyroid hormone and neonatal development. The present study was carried out to find out alterations in thyroid function tests in each trimester in normal pregnant women as compared to non-pregnant women. The study was designed with two groups of women as followed; 100 healthy pregnant women randomly selected from the first (40 samples), the second (30 samples), and the third (30 samples) trimesters, and fifty (50) randomly selected non-pregnant healthy female controls. Thyroid function tests were carried out by measuring the serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT4, T4), and free and total triiodothyronine (FT3, T3) by commercially available radio-immunoassay kits. Results: We found that mean T4 Increased progressively during pregnancy. Serum levels of T3 increased in the second trimester and then declined during the third trimester compared with non-pregnant women. We also found that FT4strongly decreased during the third trimester. Free T3 declined in the second and third trimesters. The mean TSH did not significantly differ in the three trimesters compared to the levels of non-pregnant women. Thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals to avoid misinterpretation of thyroid function during pregnancy.

Keywords: Thyroid Hormone, Total T4, Total T3, Free T4, Free T3, TSH and Pregnancy.


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