Abstract
EVALUATION OF POLYHERBAL EXTRACTS FOR IN-VITRO ANTIUROLITHIATIC ACTIVITY USING BIOENHANCER

Pradeep Bawane*, Meeta Jain, Jineetkumar Gawad, Angel Godad, SavitaTauro

ABSTRACT

Leaves of Kalanchoe pinnata, core stem of Musa paradisiaca and corn silk of Zea mays are evaluated and reported by the researchers for their antiurolithiatic activity but the activity of combination of these drugs in presence of bioenhancer like Pepper nigrum was not explored yet. The current study was design to evaluate the effect of combination of the plants with known antiurolithiatic activity with bioenhancer (piperine from pepper) by in-vitro model. Pepper enhances the bioavailability of structurally and therapeutically different drugs, either by increasing the absorption or by delaying the metabolism of the drug or by a combination of both processes. The objective of the proposed study was to assure the antiurolithic efficacy of indigenous herbs using in-vitro assays, to study alterations in activity or efficacy produced by application of bioenhancer and to examine the herbal combination for possible synergy and simultaneous determination of optimum dose or concentration of the drug as well as the bioenhancer for maximum potency. The combination was studied in presence and absence of bioenhancer & standard (Cystone) to check if any improvement in efficacy was observed which can reduce the dose of the polyherbal combination.

Keywords: Bioenhancer, Antiurolithic, Urolithiasis.


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