EVALUATION OF POLYHERBAL EXTRACTS FOR IN-VITRO ANTIUROLITHIATIC ACTIVITY USING BIOENHANCER
Pradeep Bawane*, Meeta Jain, Jineetkumar Gawad, Angel Godad, SavitaTauro
ABSTRACT
Leaves of Kalanchoe pinnata, core stem of Musa paradisiaca and corn
silk of Zea mays are evaluated and reported by the researchers for their
antiurolithiatic activity but the activity of combination of these drugs in
presence of bioenhancer like Pepper nigrum was not explored yet. The
current study was design to evaluate the effect of combination of the
plants with known antiurolithiatic activity with bioenhancer (piperine
from pepper) by in-vitro model. Pepper enhances the bioavailability of
structurally and therapeutically different drugs, either by increasing the
absorption or by delaying the metabolism of the drug or by a combination of both processes.
The objective of the proposed study was to assure the antiurolithic efficacy of indigenous
herbs using in-vitro assays, to study alterations in activity or efficacy produced by application
of bioenhancer and to examine the herbal combination for possible synergy and simultaneous
determination of optimum dose or concentration of the drug as well as the bioenhancer for
maximum potency. The combination was studied in presence and absence of bioenhancer &
standard (Cystone) to check if any improvement in efficacy was observed which can reduce
the dose of the polyherbal combination.
Keywords: Bioenhancer, Antiurolithic, Urolithiasis.
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