IMPACT OF FUNCTIONAL FOODS (ALPHA LIPOIC ACID & PROBIOTIC) ON ACETAMINOPHEN & HYPOBARIC PRESSURE INDUCED OXIDATIVE STRESS RELATED UREMIC MALE RATS
Dr. Dilip K Nandi* and Dr. Banadeb Sinha
ABSTRACT
Hypobaric pressure & acetaminophen overdoses seems to be favorable with increased oxidative damage which could be the consequence of the increased activity of ROS generating and decreased activity of antioxidant system that ultimately results in uremia. The present study is aimed to evaluate the impact of ALA & probiotic supplementation on stress induced uremia considering different biochemical parameters like urea, creatinine, MDA, SOD, catalase, RBC & hemoglobin. It was noted that serum urea, creatinine, MDA both are increased in uremic group & decreases SOD & catalase level. Acetaminophen overdoses causes the formation of NAPQI that decreases the glutathione level & causes oxidative stress. Hypobaric pressure causes hypoxia induced damage to endothelial cells, activation of cytokines, chemokines and cell adhesion molecules may orchestrate the lung inflammatory response. It cannot be ruled out that reactive oxygen (ROS) & ultimately leads to oxidative stress injury. But above theses values are resettled in treatment group & minimize the stress induced uremia. It has great societal impact on community people as it is an alternative, cost effective, affordable harmless therapy which can minimize the oxidative stress induced uremia.
Keywords: Alpha-lipoic acid; uremia; Probiotic; catalase; Oxidative stress.
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