Abstract
PHARMACOLOGICAL POTENTIAL AND MEDICINAL SIGNIFICANCE OF VERSATILE PYRIMIDINE NUCLEUS

Essa Ajmi Alodeani, Mohammad Asrar Izhari and Mohammad Arshad*

ABSTRACT

Pyrimidine nucleus has been long targeted by the researchers due to its versatile biological and pharmacological applications such as antifungal, antibacterial, antimicrobial, anti-inflammatory, antiviral, anticancer, antioxidant, antitubercular, antiparkinsonian, analgesic, antimalarial and anti-HIV activities. It is the constituent of nucleic acid including uracil, thymine, cytosine, adenine, and guanine which are the fundamental building blocks for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It also play an important role in many biological processes, such as it is found in nucleoside antibiotics, antibacterials and cardiovascular. In this review the recent development of pyrmidinre, fused pyrimidine derivatives and their potential medical importance is discussed which can be used as a guide for researchers and will be helpful for further development in this area.

Keywords: Pyrimidine derivatives, biological activities


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