Abstract
HORMONE OF DARKNESS: ROLE OF MELATONIN IN SQUAMOUS CELL CARCINOMA

Pratibha Singh Oswal*, Mayur Oswal, Mrinal Shete, Shrikant Sonune, Prasad Karande, Deepak Nagpal

ABSTRACT

Melatonin is a hormone that is produced by the pineal gland in the brain. Melatonin levels vary in 24 hour cycles and are controlled by our body clock. Normally its production is reduced by being in bright light. Levels increase at night. Melatonin has powerful antioxidant effects, functions in an immunomodulatoryrole, may protect against certain cancers, delays some age-related processes, stimulates the synthesis of type I collagen fibres and promotes bone formation. These properties have been found to be beneficial in certain oral pathologies including periodontal diseases, herpes viral infections and Candida, local inflammatory processes, xerostomia, oral ulcers and oral cancer. The objective of this review is to discuss the mechanism of action and potential role of melatonin as a preventive and curative agent for oral cancer.

Keywords: Candida, local inflammatory processes, xerostomia, oral ulcers and oral cancer.


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