European Journal of Biomedical and Pharmaceutical Sciences

CELL-PENETRATING PEPTIDES (CPP); AN EFFECTIVE TOOL IN THE MODERN TREATMENT

Mohamed Anwar Osama, Muhammad Abbas*, Suzan Adel and Dr. Huixia Lv

ABSTRACT

The present picture of novel therapeutic improvements relies mostly on gene-targeted technologies, facilitating to fight rare genomic diseases, from infections to cancer and inherited diseases. Although, reaching the action-site for this novel therapy needs to reach to nucleic acids, or other macromolecules into cells, which may face complex tasks to pharmaceutical companies. To overcome this technological shortfall, wide ranges of vectors have been developed in the past years and have confirmed to be doing well in delivering differenttherapeutics. Cellpenetrating peptides (CPP) have been one of the distinct technologies widely detail studied and have been ever more used to transfer small RNA/DNA, plasmids, antibodies, and nanoparticles into cells. Although CCP already showed huge potential that these peptide-based techniques are involve in few advances which have been put to pharmacological or clinical application. This review will portray the origin, classification, mechanism, development, and practical application of CPP to deliver therapeutic agents into cells.

Keywords: Efficient vector, Future medicine