THE EFFECT OF OCHRATOXIN A ON LIPID PEROXIDATION FROM OCHRATOXIGENIC FUNGI OBTAINED FROM DRIED CASSAVA POWDER GARRI USING AN ANIMAL MODEL.
Agu Georgia Chinemenwa*, Salami Olufunmilayo Olamide, Odusola Kikelomo B.
ABSTRACT
Ochratoxin A (OTA) is a very dangerous Mycotoxins, and hence this study aimed at determining the role of Ochratoxin in the induction of lipid peroxidation. Ochratoxigenic Aspergillus species were isolated from garri sample and re-inoculated into fresh garri to produce Ochratoxin. The extracted pure Ochratoxin A was injected into the rat model at varied concentration of 0.75, 0.81 and 0.90ml/kg weight except for the control group that received no Ochratoxin A. The lipid peroxidation was measured using an assay kit from bio-division incorporation. The result of the study revealed Aspergillus niger has the most prevalent of the isolated Ochratoxigenic fungi 36(50%) followed by Aspergillus carbonarius 36(33.3%) and Aspergillus ochraceus 36(16.7%). The Ochratoxin A was found to significantly affect the weight gained ratio (F= 185.19, 9<0.05) and the feed weight gained ratio (F=185.19, P<0.05). Also, Ochratoxin was found to have an increase the Melondialdehyde (MDA) in the treatment group relative of the control group (F=135.93, P<0.05). This study therefore clearly demonstrated a very strong link between Ochratoxin A and lipid peroxidation with this stated general objective of this study which is to investigate the role of Ochratoxin toxicity in lipid peroxidation and to investigate the effect Ochratoxin has on lipid peroxidation.
Keywords: Ochratoxin A, lipid peroxidation, Aspergillus, rat model, melondialdehyde.
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