ACUTE AND CHRONIC ALOE BARBADENSIS MILLER GEL MEDIATES ANTIULCEROGENIC AND GASTRIC ANTI-SECRETORY EFFECTS VIA HISTAMINERGIC H2 RECEPTORS
Inyang M. and *Ofem O. E.
ABSTRACT
Aloe is an ethno-pharmacological plant with huge medical potentials in alleviating myriad ailments including
gastrointestinal disorders. This study aimed to investigated the effect of chronic and acute administration of Aloe
barbadensis Miller gel on gastric acid secretion and gastric ulcers in rats. 30 albino Wistar rats were placed on
either normal rat chow + drinking water, and/or Aloe barbadensis Miller gel for 21 days. Another group (acute
group) of normal rats was only given Aloe gel on the day of sacrifice. Results revealed that gastric acid output
(GAO) reduced significantly (p<0.001) from a basal value of 2.36 ±0.76mmol/L/hr to 1.62 ± 0.30mmol/L/hr
following acute administration of Aloe gel. Chronic administration of Aloe gel significantly (p<0.01) reduced the
mean basal GAO from 4.10 ±0.14mmol/L/hr, to 2.56 ±0.29mmol/L/hr. Administration of histamine thereafter,
increased the GAO to 4.26 + 0.45mmol/L/hr and 5.02 ±0.43mmol/L/hr, in acute and chronic groups respectively,
while cimetidine reduced it to 4.20 ± 0.44mmol/L/hr and 4.9 ±0.63mmol/L/hr respectively. The mean ulcer scores
reduced significantly in the groups fed with acute (16.80 + 1.20, p<0.05) and chronic (10.4 +1.75, p<0.01) Aloe
gel compared with control (24. 20 + 3.11). In conclusion, Aloe barbadensis Miller gel appears to be a potent
inhibitor of gastric acid secretion and cyto-protective agent under normal physiological conditions, possibly via
blocking the H2-histaminergic receptor.
Keywords: Aloe Barbadensis Miller gel, gastric secretion, ulcer, rats.
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