European Journal of Biomedical and Pharmaceutical Sciences

FASTING VS. NON FASTING LIPID PROFILE AMONG SUDANESE IN KHARTOUM STATE

Lena Mohamed Ahmed Rizig* and Dr. Tarig Mohamed Fadl-Elmola

ABSTRACT

Background: Lipid profile is always measured in fasting state as recommended by national and international guidelines. Recent studies have suggested that the lipid profile results are not significantly changed in response to food intake, moreover some studies concluded that non fasting lipid profile is more useful in predicting adverse cardiovascular outcomes. This study was conducted to investigate the association between fasting and non fasting lipid profile. Methodology: cross sectional study conducted over 6 months period since November 2015,the study included randomly selected 60 individuals in the age group 20-60 years, fasting and non-fasting blood samples were obtained from each individual and lipid profile was performed using enzymatic methods for cholesterol, triglycerides and HDL. LDL was calculated with Friedewald formula. Results: The study included 60 adult individuals, age group 20-60 years, 28 (46.7%) were males and 32 (53.3%) were female. The mean difference between fasting and non-fasting for all lipid profile was not significant indicated by p.values more than 0.05. For males p-values were (0.675, 0.806, 0.870 and 0.826) for cholesterol, triglycerides, HDL and LDL respectively and (0.080, 0.484, 0.449, 0.053) for females. Triglycerides had the most changed levels in both males and females with a mean difference of 8 mg/dl in males and 12 mg/dl in females, where HDL showed the least variation with a mean difference of 1 mg/dl in females and 3 mg/dl in males. The population was farther divided by their health status into normal, diabetic, dyslipidemic and hypertensive, there was no great difference in the results between these subgroups where all groups have p-values more than 0.05 for all lipid subclasses indicating no significant difference between fasting and non-fasting status. Conclusion: In conclusion, this study illustrated that nonfasting lipid profile have no significant difference from fasting lipid profile, including triglycerides. Guidelines which recommend fasting for lipid analysis should be reconsidered.

Keywords: Fasting, Non fasting, lipid.