MICROSPONGE A NOVEL NEW DRUG DELIVERY SYSTEM: A REVIEW
Swapnil Lembhe* and Asish Dev
ABSTRACT
The Microsponge Drug Delivery System (MDS) is a patented technology has been successively used for the
controlled release of topical agents which consist of macro porous beads, typically 10-25 microns in a diameter,
which are loaded with active agent. Allowing a sustained flow of substances out of the sphere, the outer surface is
typically porous, This system can suspend or entrap a wide variety of substances, and incorporated into a
formulated product such as a liquid, gel, cream, or powder The Microsponge shows time mode release when
applied to the skin and they also response to other stimuli like rubbing, pH, etc. MDS technology is currently used
in different dosage forms like cosmetics, over the counter (OTC) skin care, sunscreens and prescription products.
Microsponge technology allows entrapment of ingredients and it also shows reduced side effects, more stability,
increased elegance and enhanced formulation flexibility. In addition, various studies have showed that
microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. Microspheres can be
prepared by different methods using emulsion system or by suspension polymerization in liquid system.
Keywords: Microsponge, Porous-beads, controlled-release, Quisi-emulsion-solvent-diffusion method, Liquidliquid- suspension-method.
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