European Journal of Biomedical and Pharmaceutical Sciences

NON-CLASSICAL ESTROGEN/XENOESTROGEN RECEPTOR SIGNALLING IN MODULATION OF NEURONAL FUNCTION

Abhay Kumar Pandey*

ABSTRACT

Significance of fast signalling membrane-linked nonclassical estrogen receptors has emerged in recent years to understand biological consequences of exposure to many environmental estrogenic substances. Any menace from fast signalling receptor function should primarily affect excitable tissue functions eg.the nervous system. Both peripheral and higher functions may be subject to infringement. Architecture of estrogen receptors; their interaction with ligands and dynamics are all very complex, associated with peculiar variation of outcomes as per the contexts. Receptor molecules, their association molecules, signaling cascades and second messengers exhibit differences based on contexts. The challenge for progress of physiological and pharmacological understanding of biologic involvement of estrogens in health and disease of organs and human being demands the defining of patterns amidst the chaos. This is timey attempt to review the context, as environmental estrogens acquire greater place among ubiquitous pollutants.

Keywords: Membrane estrogen receptors; Endocrine disruptors and nervous function; Nervous estrogenic action.