European Journal of Biomedical and Pharmaceutical Sciences

NON-CLASSICAL BIOACTIVITY OF ENVIRONMENTAL ESTROGEN BISPHENOL A, WITH A FOCUS ON NEUROPHYSIOLOGY

Abhay Kumar Pandey*

ABSTRACT

Bisphenol A is synthetic biphenolic intermediate used in making polycarbonate plastic, epoxy resin and flame retardants. It’s the most ubiquitous environmental estrogen and endocrine disruptor, to which human population is exposed across the globe. Classical genomic effects are toxic to developmental and reproductive biology. Feminizing effects have threatened existence of some aquatic species and seriously depress human sperm count. The complex multifaceted mechanisms of diverse bioactivity of bisphenol A need urgent understanding, given the magnitude of hazard. Activity Spectrum of bisphenol beyond classical genomic effects, currently leads to new revelations of steroid hormone physiology. Very importantly the effects on nervous function have attracted attention. The progress in this specific context is obviously, crucial to evolving appropriate preventive and corrective strategies for exposed massive population. The aspect is briefly reviewed.

Keywords: Bisphenol A, Endocrine disruptor, xenoestrogen, environmental toxicology, biphenolics.