Abstract
NOVEL PHARMACEUTICAL APPLICATION OF MIXED SOLVENCY CONCEPT FOR DEVELOPMENT OF SOLID DISPERSIONS OF PIROXICAM

Rajesh Kumar Maheshwari, Naveen Chaklan and Sugandha Singh*

ABSTRACT

Based on the large number of experiments on solubilization of poorly water-soluble drugs ,The auther is of the opinion that hydrotropy is another type of cosolvency and all water soluble substances whether solids, liquids or gases have solubilizing properties. Therefore, an aqueous solution containing small quantities of several water-soluble excipients giving a concentrated solution may act as a solvent system for some poorly water-soluble drugs. This is example of the concept of mixed solvency. This same concept has been explored to formulate the solid dispersions of poorly water soluble drug piroxicam. And Solid dispersions were evaluated for flow property, powder x-ray diffraction, differential scanning calorimetric studies, scanning electron microscopy, dissolution studies and stability studies.

Keywords: Mixed solvency, hydrotropy, piroxicam, solid dispersion.


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