EVALUATION OF SERUM CREATININE, EGFR AND INSULIN-LIKE GROWTH FACTOR 1 IN HYPOTHYROID SUBJECTS BEFORE AND AFTER L-THYROXINE REPLACEMENT
Trinanjan Sanyal, Sujoy Ghosh and Subhankar Chowdhury
ABSTRACT
Aims of our study: To detect any renal compromise if at all present in hypothyroid state and whether such
compromise is correctable by levothyroxine (LT4) replacement. Methodology: A longitudinal, self-controlled
study was performed with 23 Drug-naïve (untreated) primary hypothyroid patients aged between 18 to 60 years
with normal urinary findings, no recent therapy with cephalosporin (within two weeks) and with a normal
creatinine level (up to 1.3mg/dl). Fasting blood samples were taken for serum IGF1 (insulin-like growth factor 1)
& serum creatinine. Then the patients were advice to take daily L-thyroxin (1.6 microgram/kg/day) and reviewed
at least after eight weeks and fasting blood samples were taken for serum creatinine and serum IGF1 provided the
patients achieved euthyroid state. Serum creatinine, IGF-1 and eGFR values before and after levothyroxine
therapy were compared statistically. Results: Before and after treatment changes were TSH (86.33 ± 51.9 to 2.60
± 1.34), IGF-1(182.6 ± 129 to 204.2 ± 118.9) Serum creatinine (0.92 ± 0.23 to 0.77 ± 0.16) and eGFR (88.39 ±
33.82 to 104.8 ± 26.39). All of the changes were significant. A significant negative correlation between change in
TSH and change in serum creatinine but positive correlation between change in IGF1 & change in eGFR were
found. Conclusion: We conclude from our study to consider evaluation of thyroid functions in all CKD patients
and to treat hypothyroidism with an expectation of improvement of renal function that may delay the progression
of the disease to ESRD and a mild renal compromise if found in hypothyroid state should not be unnecessarily
investigated before adequate thyroid hormone replacement.
Keywords: Serum Creatinine, Insulin-Like Growth Factor 1, Hypothyroid, L-thyroxine supplementation
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
