European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION, DEVELOPMENT AND EVALUATION OF FLOATING DRUG DELIVERY SYSTEM OF CEFPODOXIME PROXETIL

Manish Kumar Bhatt, Bhupendra Nath Dwivedy and Viney Chawla*

ABSTRACT

In the present research work, floating matrix tablets of Cefpodoxime proxetil were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Cefpodoxime proxetil was chosen as a model drug because it is well absorbed from stomach and upper part of small intestine. Absorption profiles in acidic pH make this drug a suitable candidate for formulating it as gastro retentive dosage form for improved bioavailability. Preformulation studies were carried out to optimize the required quantity for HPMC-E15, Locust Bean Gum, Xanthan Gum. Fourier transform Infrared spectroscopy confirmed the absence of any drug/polymers/excipients interactions. A total of nine batches of floating tablets of Cefpodoxime proxetil were prepared by direct compression technique, using polymers such as Hydroxypropylmethyl Cellulose (HPMC-E15), Locust bean gum, Xanthan gum in different combinations with other standard excipients like Sodium bicarbonate, Citric acid, Magnesium Stearate and Talc. Tablets were evaluated for physical parameters viz. hardness, friability, swelling index, floating capacity, thickness and weight variation. Further, tablets were evaluated in-vitro for drug release up to 9 hr. The effect of polymer concentrations on buoyancy and drug release pattern was also studied. All the matrix tablets showed significantly greater swelling index and exhibited controlled and prolonged drug release profiles and some floated over the dissolution medium for more than 12 hr. The paddle speed had a negative effect on the floating lag time and floating duration. The optimized formulation followed the Higuchi release model and showed non-Fickian diffusion mechanism.

Keywords: Cefpodoxime proxetil, Swelling index, Floating capacity, Locust bean gum, Xanthan gum, HPMC, Controlled release formulation.