Abstract
COMPARISON OF OPHTHALMOLOGICAL COMPLICATIONS OF ANTIVIRAL DRUGS FOR HCV INFECTION

Prempal Kaur*, Baljinderpal Singh and Bhavkaran Singh Bal

ABSTRACT

Purpose Of the Study.The study was conducted to compare the ophthalmological complications of Pegelated interferon, ribavirin combination with recently approved direct acting oral anti viral drugs sofosbuvir and daclatasvir. Material And Methods. 120 patients of HCV selected for the study were divided into four Groups .Group A (50) received pegelated interferon alpha (INF) and ribaveriin (RBV) for 24 weeks,Group B (25) INF,RBV and sofosbuvir (SOF) for 12weeks Group C (25) SOF and RBV for 24 weeks and Group D (20) SOF and Daclatasvir for 12 weeks. Retinal examination was done at baseline, 4,8,12 and 24 weeks during treatment and 4 weeks after completion of treatment. Results: Fifteen patients developed retinopathy in the form of cotton wool spots and hemorrhages, 12 in Group A,3 in Group B and none in Group C and D. Despite retinopathy treatment was completed and BCVA of 6/6 was maintained in all except in two patients ,one each in Group A and Group B. They lost vision due to cystoid macular edema and treatment was discontinued. One lost to followup and other recovered 6/6 vision. Conclusions: Retinopathy was detected only in those HCV patients who were taking INF as part of their treatment. With newer combinations tolerability and compliance has increased .Effective and safe treatment of all genotypes of HCV with interferon free, SOF based oral regimens is now becoming a reality and we can look forward to total eradication of HCV infection.

Keywords: Hepatitis, Interferon, Ribavirin, Retinopathy.


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