Abstract
INDOCYANINE GREEN TRANSFEROSOMAL HYDROGEL WITH ENHANCED STABILITY AND SKIN PERMEATION FOR TREATMENT OF ACNE VULGARIS: (IN-VITRO AND CLINICAL STUDY)

Maha Fadel, Kawser Kassab, *Nevien Samy and Sarah Thabet

ABSTRACT

Background: Topical Delivery in photodynamic therapy (PDT) is a complicated task with often unsatisfactory results. Objective: Developing Indocyanine green (ICG) transfersomal hydrogel to enhance its dark- and- photostability, as well as improving its topical delivery as photodynamic sensitizer. Methods: Two transfersomal preparations entrapping ICG either in the lipid membrane or the aqueous core were formulated. Both formulations were studied, for some pharmaceutical properties, entrapment efficiency for ICG as well as ICG dark- and- photostability. The formula of higher loading capacity for ICG, longer shelf life time (in dark) as well as photostability, was formulated in topical hydrogel and further studied for in vivo permeation study on dorsal mice skin and evaluated clinically for PDT of acne vulgaris, after irradiation with 820 nm using diode laser. Results: Entrapping ICG in transfersomes enhanced its dark- and- photostability. Histological examination of mice dorsal skin demonstrated that topical PDT with transferosomal ICG provided photodamage at deeper regions of mice skin in comparison to aqueous ICG hydrogel. Clinical evaluation revealed marked improvement in the inflammatory lesion (papules and pustules) counts with more than 80% clearance after 3 sessions till the end of follow up period compared to free ICG gel which showed 45 % improvement at the end of the follow up period. Conclusion: Formulating of ICG in transfersomal hydrogel significantly increased its shelf life time and photo-stability. Moreover, it improved its photodynamic properties as a topical sensitizer for treatment of acne vulgaris, compared to aqueous ICG hydrogel.

Keywords: Indocyanine green. Transfersomes. Photostability. Photodynamic therapy


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