European Journal of Biomedical and Pharmaceutical Sciences

CHANGE IN SERUM MAGNESIUM LEVEL IN PRE AND POST HEALTHY PLATELETPHERESIS DONORS.

V. B. Mane*, P. E. Jagtap, N. S. Nagane, G. J. Belwalkar, S. P. Dhonde and Y. R. Gotekar

ABSTRACT

Background: Plateletpheresis (more accurately called thrombocytapheresis or thrombapheresis, though these names are rarely used) is the process of collecting thrombocytes, more commonly called platelets, a component of blood involved in blood clotting. The term specifically refers to the method of collecting the platelets, which is performed by a device used in donation that separates the platelets and returns other portions of the blood to the donor. Platelet transfusion can be a life-saving procedure in preventing or treating serious complications from bleeding and hemorrhage in patients who have disorders manifesting as thrombocytopenia (low platelet count) or platelet dysfunction. This process may also be used therapeutically to treat disorders resulting in extraordinarily high platelet counts such as essential thrombocytosis.[1] We planned this study to observe the effect of citrate infusion in plateletpheresis donors and to determine whether the biochemical alteration had any clinical consequences and also focus the altered mineral metabolism in first time plateletpheresis donation. Study design and methods: The study was conducted on 62 healthy first time voluntary plateletpheresis donors with age group between 21 to 50 years, at Apheresis unit in blood bank Bharati Vidyapeeth Deemed University Medical College & Hospital, Sangli. Plateletpheresis procedures were performed by using cell separator machine Fenwal Amicus Cell Separator (Baxter Healthcare Corporation Deerfield IL USA). Biochemical values of serum magnesium were measured in all 62 donors, pre and post apheresis procedure. Result: We observed that the serum magnesium decreased significantly in the plateletpheresis donors (p < 0.001) after each procedure in all donors. Conclusion: Infusion of Acid Citrate Dextrose an anticoagulant and its catabolic reactions possibly responsible for the altered levels of serum magnesium .In the context we suggest the donor should be screened for biochemical investigation serum magnesium along with the serological and hematological investigation at first time plateletpheresis donation. These biochemical investigations will be definitely useful in providing the transfusion consultant in the management of plateletpheresis complications.

Keywords: ACD infusion; Biochemical levels; Citrate side effect; Hypomagnesaemia; Plateletpheresis.