DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF ZALEPLON
Hemendra Pratap Singh, Kapil Kumar* and Sai Krushna Padhy
ABSTRACT
At present scenario transdermal drug delivery systems has gained a lot of interest due to many advantages over the
conventional dosage forms and oral controlled release delivery systems notably avoidance of hepatic first pass
effect, less frequency of administration, reduction in gastrointestinal side effects and improves patient compliance.
Zaleplon is a pyrazolopyrimidine derivative having sedative and hypnotic properties. It’s properties like low
molecular weight, favorable logarithmic partition coefficient, smaller dose (1mg to 10mg), short elimination halflife
and poor oral bioavailability (30.6±10.2%), indicates need to develop a novel drug delivery systems. Different
transdermal patches were prepared using different polymers and evaluated on many parameters. Accelerated
stability studies for 12 weeks revealed that the transdermal patches formulations were stable at up to 450C. The
stability study of the optimized formulation showed satisfactory characteristics without being drastically
influenced. Locally fabricated Franz diffusion cell was used for the in-vitro release study.
Keywords: Zaleplon, transdermal patches, HPMC, in-vitro release, stability studies, TDDS.
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