Abstract
EVALUATION OF ANALGESIC ACTIVITY OF A POLYHERBAL FORMULATION IN ALBINO RATS

K. Hari Kamesh Kiran*, Dr. A. Lakshman Rao and A. Tirupathi Rao

ABSTRACT

The present study was aimed to investigate the analgesic activity of the ethanolic extract of a polyherbal formulation in rats. The polyherbal formulation is made of leaves of Datura stramonium, rhizome of Zingiber officianale & fruits of Piper longum and it were taken as two doses i.e., 200, 300 mg/kg to evaluate the analgesic activity by Tail flick method and Acetic acid induced writhing test. The results of present study show that polyherbal formulation possesses significant analgesic activity in all tested experimental animals. The study may conclude that Polyherbal formulation possesses central analgesic activity which was evaluated using Tail flick method and peripheral activity in Acetic acid induced writhing test.

Keywords: Analgesic activity, peripheral activity, central analgesic, writhing, Tail flick.


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