Abstract
INFLUENCE OF SILK SERICIN FROM THE COCOONS OF SILKWORM, ANTHERAEA MYLITTA (L) AND BOMBYX MORI (L) ON HYDROGEN PEROXIDE INDUCED OXIDATIVE STRESS IN FELINE FIBROBLASTS.

Vitthalrao B. Khyade*

ABSTRACT

The attempt is concerned with assessment of potential regarding antioxidant activity of Sericin from silk from cocoons of non-mulberry silkworm, Antheraea mylitta and mulberry silkworm, Bombyx mori (L) through the use of hydrogen peroxide induced stress in skin fibroblast cell line culture (AH927). Cells treated with sericin exhibited significant cell viability comparable to that of control group (P < 0.05). The fibroblasts pre-incubated with sericin of both the species at 100 ng/ml had significantly decreased (P <0.01) catalase activity. The oxidative stress through hydrogen peroxide was found responsible for significant increase (P <0.01) in the release of enzyme (LDH) in comparison with untreated control. The sericin treatment definitely serving to restore the original membrane integrity of the cells. The aqueous form of silk sericin, from a natural source like silkworm cocoon, serve as ideal antioxidant source and may be used to treat the cancer cells.

Keywords: Antioxidant activity, Fibroblast cell line, Hydrogen peroxide, Oxidative stress, Moracin


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