Abstract
DEVELOPMENT, OPTIMIZATION AND EVALUATION OF GUAR GUM AND SCMC BASED IPN HYDROGEL BEADS FOR CONTROLLED DRUG DELIVERY OF CAPTOPRIL

Himanshi Joshi*, Ganesh Kumar Bhatt, Alka Lohani and Preeti Kothiyal

ABSTRACT

Interpenetrating polymeric networks hydrogel beads of guar and sodium carboxy methyl cellulose (SCMC) containing captopril, an angiotensin converting enzyme inhibitor were prepared by single water in water emulsion Gelation technique using AlC3 as a cross-linker. Various formulations were prepared by altering the polymer ratio, concentration of cross-linker, and curing time for bead preparation. The IPN hydrogel beads formulations were optimized, developed and evaluated successfully by Fourier transform Infra-red (FTIR) & scanning electron microscopy (SEM). From the prepared formulation it was found that the beads were spherical in shape and were free flowing. The prepared beads showed elevated drug encapsulation efficiency along with extended release of drug in intestine. Maximum % drug encapsulation efficiency was found to be 85.43 ± 0.074, where as the swelling studies showed that prepared beads are pH sensitive and it has a high ability to swell in alkaline medium as compared to acidic medium. The resultant value from swelling studies showed that as the concentration of cross linker increases, water uptake capacity has decreases. Also percentage cumulative drug release was performed in both acidic and basic medium. The results demonstrate that only 13.49% to 24.84% drug was released in acidic medium pH(1.2), whereas 58.56% to 87.34% drug was released in alkaline medium pH(7.4) within 10 hours of study. Finally from power plotting of drug release it was found that the formulations showed zero order release kinetic and the release of drug IPN hydrogel beads followed Non-Fickian type transport mechanism. The results of all formulations, indicates that the drug releases in acidic medium was decreases and increases in alkaline medium which would help to minimize the gastric side effects of captopril.

Keywords: captopril; guar gum; SCMC; cross-linker; emulsion Gelation method.


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