DEVELOPMENT, OPTIMIZATION AND EVALUATION OF GUAR GUM AND SCMC BASED IPN HYDROGEL BEADS FOR CONTROLLED DRUG DELIVERY OF CAPTOPRIL
Himanshi Joshi*, Ganesh Kumar Bhatt, Alka Lohani and Preeti Kothiyal
ABSTRACT
Interpenetrating polymeric networks hydrogel beads of guar and sodium carboxy methyl cellulose (SCMC)
containing captopril, an angiotensin converting enzyme inhibitor were prepared by single water in water emulsion
Gelation technique using AlC3 as a cross-linker. Various formulations were prepared by altering the polymer
ratio, concentration of cross-linker, and curing time for bead preparation. The IPN hydrogel beads formulations
were optimized, developed and evaluated successfully by Fourier transform Infra-red (FTIR) & scanning electron
microscopy (SEM). From the prepared formulation it was found that the beads were spherical in shape and were
free flowing. The prepared beads showed elevated drug encapsulation efficiency along with extended release of
drug in intestine. Maximum % drug encapsulation efficiency was found to be 85.43 ± 0.074, where as the swelling
studies showed that prepared beads are pH sensitive and it has a high ability to swell in alkaline medium as
compared to acidic medium. The resultant value from swelling studies showed that as the concentration of cross
linker increases, water uptake capacity has decreases. Also percentage cumulative drug release was performed in
both acidic and basic medium. The results demonstrate that only 13.49% to 24.84% drug was released in acidic
medium pH(1.2), whereas 58.56% to 87.34% drug was released in alkaline medium pH(7.4) within 10 hours of
study. Finally from power plotting of drug release it was found that the formulations showed zero order release
kinetic and the release of drug IPN hydrogel beads followed Non-Fickian type transport mechanism. The results of
all formulations, indicates that the drug releases in acidic medium was decreases and increases in alkaline medium
which would help to minimize the gastric side effects of captopril.
Keywords: captopril; guar gum; SCMC; cross-linker; emulsion Gelation method.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
