European Journal of Biomedical and Pharmaceutical Sciences

PROFILE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN OF URINARY BACTERIAL ISOLATES AT A TERTIARY CARE HOSPITAL IN CENTRAL INDIA

Chaudhari Vijaya Laxman* and Patil Asmita Ashok

ABSTRACT

Aim: to study the antimicrobial susceptibility pattern in urinary bacterial isolates among patients admitted in a tertiary care hospital. Methods: A retrospective analysis was done for the susceptibility pattern of urinary bacterial isolates was done over a period of three years (April 2007 – March 2010) in a tertiary care hospital. Results: Among total 3759 urinary culture positive samples, commonest isolates were E. coli (61.59%) followed by Klebsiella spp. (25.46%), Pseudomonas spp. (3.72%), and Proteus spp. (0.85%) in gram negative whereas Staphylococcus aureus (5.69%) and Enterococcus spp. (1.33%) in gram positive organisms. Antibiotic susceptibility pattern of these isolates revealed that Amikacin susceptibility in gram negative isolates was more than 60% except for Proteus spp. Sensitivity to Imipenem was maximum (above 90%) while Co-trimoxazole, Norfloxacin, Cefotaxime and Nalidixic acid were not found to be effective. Among gram positive organisms, maximum susceptibility was seen to Nitrofurantoin and Vancomycin. Conclusion: Routine urine culture and susceptibility before therapy should be encouraged and periodic evaluation of predominant organisms and their antimicrobial susceptibility pattern should be studied for appropriate selection of antibiotic for effective management UTI cases.

Keywords: Acinetobacter spp, E.coli, Imipenem, Indoor, Resistance Pattern.