European Journal of Biomedical and Pharmaceutical Sciences

AMELIORATION OF CISPLATIN-INDUCED TOXICITY IN BLOOD DOMESTIC RABBIT'S BY SODIUM THIOSULFATE OR GINGER EXTRACT

Ayoub R. Aldalou*

ABSTRACT

Cisplatin is a chemotherapeutic agent that is widely used to treat a variety of malignant tumors. A comparative studies were performed to assess the protective effects of sodium thiosulfate or ginger extract on cisplatin-induced toxicity in some blood hematological and biochemical parameters of twenty eight domestic rabbits. Animals were divide into four groups, the first was comprised 10 rabbits and given 1 ml saline intramuscularly and kept as a control. The second group (6 rabbits) received 5 doses of cisplatin at a dose of 5mg/kg b.wt. i. m. once/day, the third group (6 rabbits) received the previous dose of cisplatin plus sodium thiosulfate at a dose of 0.4gm/kg b.wt. i. m. once/day for 5 days, while the fourth (6 rabbits) given the same dose of cisplatin plus 100mg/ kg b.wt of ginger extract (given orally) once/day for 5 days. In the present study, sodium thiosulfate administration concomitantly with cisplatin reduced cisplatin-induced lesions in a significant manner. These finding suggest that sodium thiosulfate or ginger extract so effectively, reduces cisplatin-induced toxicity and there use concomitantly with cisplatin are highly recommended. It was found in this study that ginger extract more potent against cisplatin than sodium thiosulfate in many biochemical and hematological changes.

Keywords: Cisplatin, sodium thiosulfate, ginger extract, rabbits, blood.