Abstract
SYNTHESIS AND IN VITRO ANTITUMOR ACTIVITY OF QUINAZOLINE-4(3H)-ONE DERIVATIVES WITH DITHIOCARBAMATE SIDE CHAINS

Saritha J. Tangeda*, Anuradha Sandala and Achaiah Garlapati

ABSTRACT

A series of quinazoline-4(3H)-one derivatives with dithiocarbamate side chains were synthesized to investigate cytotoxic activity. Final compounds (5a-5o) were confirmed by spectral data and elemental analysis. Synthesized compounds were tested for antitumor activity against K562 (leukemia), Colo-205 (colon cancer) and MDA-MB (Breast cancer) by MTT assay method. Title compounds were prepared by reacting corresponding 3-amino-2-phenylquinazoline-4(3H)-ones with carbon disulfide and various alkyl/aralkylhalides in dimethylformamide. Physicochemical and spectral data were consistent with newly synthesized compounds. Among the series, compound 5p (IC50 = 14.6 μM) showed significant antitumor activity against K562 cells.

Keywords: Quinazoline-4(3H)-one, dithiocarbamates, anticancer activity, MTT assay.


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