SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLE OF GINGER RHIZOME (ZINGIBER OFFICINALE) EXTRACT: SYNTHESIS, CHARACTERIZATION AND ANTI DIABETIC ACTIVITY IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Ashish Garg*, Prakash Pandey, Prabhakar Sharma and Ajay Shukla
ABSTRACT
In the current work, the antidiabetic potentials of silver nanoparticle of ethanolic extaract of ginger rhizome (Zingiber officinale) (SNEG) were studied in rats. Now a days a vast research is going in the field of metal and semiconductor nanoparticles as they have very potent application in the development of novel delivery system, In present work a economic and very favourable method is described for the synthesis of silver nanoparticles and ethanolic extract of Zingiber officinale rhizome through silver nitrate solution is used for the evaluation of antidiabetic activity. Various analytical methods such as Atomic Force Microscopy, X-ray Diffraction and Fourier Transform Infrared Spectroscopy were employed for monitoring the formation of nanoparticles. Presence of silver nanoparticles with an average size of 123.8 nm was revealed by Atomic Force Microscopy. The crystalline nature of synthesized nanoparticles was done by X-ray diffraction. This work shows that silver nanoparticles have good antidiabetic activity in comparison with standard hypoglycaemic agents, hence more work and investigation for clinical application is necessary.
Keywords: Antidiabetic activity, Fourier Transform Infra Red Spectroscopy, Silver nanoparticles, X-Ray Diffraction, Zingiber officinale.
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