European Journal of Biomedical and Pharmaceutical Sciences

EFFECT OF CIGARETTE SMOKING ON SERUMAND SALIVALIVER ENZYMES FUNCTION.

Abdul-Wahab R. Hamad*, Khaled, N. Al-Kubaisy, Saied M. Al-Daline and Faker Al-Ani

ABSTRACT

Background: Smoking may affect the liver through inflammatory pathways and may aggravate the pathogenic effects of smoking on the liver. The study has examined the relationship between cigarette smoking and liver enzymes function. Methods: The subjects consisted of 100 men aged 19-25years with no history of any diseases. The saliva and blood was withdrawn from each subject. Biochemical assays for saliva and serum enzymes ALP, AST, ALT, LDH and GGT were performed in all subjects (control and smokers). All assays were performed at the college laboratory. Results: The results showed that serum and saliva enzymes ALP, ALT, AST, LDH, and GGT levels were significantly high (P value<0.05) in smoker group when compared with nonsmoker group. Cigarette smoking was significantly associated with increased levels of gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), (P < 0.05) and was inversely associated with increased aspartate aminotransferase (AST) after adjustment for smokers. Conclusions: Smoking affects the individual components of liver enzymes function in different ways on liver function tests. Therefore, their effects on enzymes liver function should be carefully interpreted, and further study on the mechanism of the effects is warranted.

Keywords: Smoking, alkaline phosphatase (ALP), aspartate amino transferase (AST), alanine aminotransferase (ALT), ?-glutamyltransferase (GGT) and Lactate dehydrogenase (LDH).