EVALUATION OF EVIDENCE BASED ADVERSE DRUG REACTIONS AND PHARMACOVIGILANCE USING ASSESSMENT SCALES IN TERTIARY CARE TEACHING HOSPITAL
Venkata Rama Rao Nallani*, Dr. Rama Rao Nadendla and Dr. Zahedabano
ABSTRACT
OBJECTIVE: Evaluation of evidence based adverse drug reactions and Pharmacovigilance assessment scales in tertiary care teaching hospital. MATERIALS & METHODS: The study is an observational Prospective was designed from January 2014 to June 2016 (30 months) in which incidence of adverse drug reactions was calculated. A total of 450 adverse drug reactions were observed from 5640 patients. Pharmacovigilance assessment on adverse drug reactions were assessed by five international scales based on causality, probability, severity, preventability and type of class. These scales as follows Causality by WHO-UMC Scale, Probability by Naranjo’s scale, and Severity by Hartwig & Siegel scale, Preventability by Modified Schumock & Thornton and type of classification by modified by Wills and Brown. RESULTS: Prevalence of ADR’s was found to be 8.02% and male to female ratio was 0.81. ADR’s mostly occurred in the age group 41-50 (57.4%). Ski and gastrointestinal was found to be the most commonly affected organ system (24.29%) among which rashes and urticaria were the most common type of ADR’S reported, majority of the adverse drug reactions were due to Antimicrobials (22.42%). For Casuality of ADR’s according to Naranjo Scale 26.16% of adverse drug reactions were assessed to be probable, using WHO-UMC scale 33.64% were considered as probable. Similarly Severity assessment shows majority of the reactions as moderate (53.27%). CONCLUSION: Adverse drug reactions are commonly observed in wards because of wrong administrations and dose, other factors genetically drugs produce reactions. one should need to observe the patient prescription and compliance towards medications. so that we can minimize the adverse drug reactions.
Keywords: ADR’s mostly occurred in the age group 41-50 (57.4%).
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