Abstract
TOXICOPAHOLOGICAL EVALUATION OF TRADITIONAL MEDICINE PALAKALYANA GHRITHA IN SPRAGUE DAWELY RATS

Kariyakeranage Chandi Perera*, Dilani Lokuhetty, Sumeda Wijeratne and Deepal Mathew

ABSTRACT

Palakalyana Ghrita is a polyherbal traditional medicine commonly used in Sri Lanka to revitalize and enhance reproductive functions of human. However there is no scientific evidence on toxico- pathological effects of this drug if any. Present study evaluated presence of any acute and subacute toxic effects of this drug in Sprague Dawley rats. In acute toxicity study, four groups of rats (n = 5 / group / sex) were orally treated with single dose of 0 .25, 0.5, 2.0 and 4.0 g / kg body weight followed by 24 hr observation for signs of toxicity. Subacute toxicity test was performed by oral administration of doses of PKG 0. 5, 2.0 and 4.0 g / kg body weight daily for 14 days. Any signs of toxicity, weight, basic haematological parameters, liver function tests, and histopathological evaluation of selected organs were performed on sub-acute treated and control groups. There was no toxic signs observed in the acute toxicity study compared to control group. Biochemical and hematological parameters were unaltered in both test and control rats of the sub-acute group. (P> 0.05). Moreover, two male rats treated with 4.0 g / kg, for 14 days showed renal tubular epithelial necrosis while rats subjected to other dosages did not reveal any organ impairment. As no significant changes of histopathological, biochemical or haematological parameters occurred in rats subjected to the dosage up to 2 g / kg / body weight of both genders, it can be used as the maximum non- toxic dose.

Keywords: Acute toxicity, Palakalyana Ghrita, Sub- acute toxicity, Sprague Dawley.


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