European Journal of Biomedical and Pharmaceutical Sciences

THE FREQUENCY OF PLATELET RECEPTOR GP IIB POLYMORPHISM IN SUDANESE PATIENTS WITH HYPERTENSION

Amel Osman Abdelmoula Osman*, Mohaned Eltayeb Mohamed Ahmed and Ibrahim Khider Ibrahim

ABSTRACT

Background: Glycoprotein II b it is a receptor on platelets for fibrinogen and von will brand factor and aid in platelet activation, aggregation and adhesion to sub indothelial .glycoprotein found in chromosome 17 and defect in it will cause many disease. Objective: The purpose of this study was to investigate the frequency of the GP IIb polymorphism in hypertension patients in sudan. Material and Methods: Forty three hypertension patients and forty four controls were participated to detect the frequency of G.P IIB polymorphism. Platelet count and indices were performed by an automated cell analyzer. The G.P IIB polymorphism was detected using RFIP-PCR. Results: The wild genotype for G.P IIB were detected in 17 of patients and 27 of the control; the heterozygous genotype were 22of patients and 12 of control and the homozygous genotype were 5 for patients and 5 for control and the difference was not statistically significant(P.value 0.496). Conclusion: The control group genotype and patients as in table(1); the allele frequency for control was: a=0.75 ,b=0.25.while the allele frequency for the patients was: a=0.67 ,b=0.33. However, a significant deviation from the Hardy- Weinberg equilibrium was observed in control group(X2=3.27, df=1 and p.v>0.05) and for patients group(X2=9.52 ,df=1 and p.v=0.001.

Keywords: Hypertension, Platelets, Polymorphism, G.PIIB.