METAL COMPLEXES: EFFECTIVE APPROACH FOR THE MANAGEMENT OF DIABETES MELLITUS
*Benjamin Chibuzo Ejelonu
ABSTRACT
Inorganic medicinal chemistry is a rapidly developing field with enormous potential for applications, which offers new possibilities to the pharmaceutical industry. For example, the titanocene dichloride is already in clinical use, and antimetastatic activity of a range of Ru (III) complexes is also well established. Ligand design allows paramagnetic ions to be targeted to specific organs. Such designed ligands also enable the targeting of radiodiagnostic and radiotherapeutic isotopes. There is a significant progress in understanding the coordination chemistry and biochemistry of metal ion(s) containing complexes such as antibacterial, antifungal, antiarthritic, antiinflamatory and antiulcer drugs. Progress in coordination chemistry is strongly dependent on understanding not only the thermodynamics of reactions, but also the kinetics of metal complexes under biologically relevant conditions. The expanding knowledge of the role of metals in biochemistry is expected to provide scope for the design of new drugs in many other areas such as neuropharmaceutical and hyperglycemic agents. Therefore this review is design to focus on the importance of metal complexes in managing one of the global public health problem in the twenty-first century called diabetes mellitus.
Keywords: Metal complexes, Diabetes mellitus, Pharmaceutical.
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