European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF DISPERSIBLE TABLETS OF OLMESARTAN MEDOXOMIL

B.Venkateswara Reddy*, N.Theja Vinod Kumar, K.Navaneetha

ABSTRACT

The purpose of this research work was to develop and evaluate dispersible tablets of Olmesartan medoxomil employing different ratios of hydrophilic polymers by direct compression method. The main objective is to avoid first pass effect and to improve bioavailability of Olmesartan medoxomil which is used in the treatment of hypertension. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Total of 12 formulations consisting of Low substituted Hydroxy propyl cellulose, sodium starch glycolate and crospovidone in the different ratios were prepared. The prepared dispersible tablets were evaluated for in vitro drug release, moisture loss and mechanical properties. The formulations coded as F6 (Crospovidone) showed maximum release of 98.34% within 14 mins. The formulation F6 emerging to be ideal formulation for Olmesartan medoxomil. The stability studies were carried out on the most satisfactory formulation F6 and there was no significant difference in the physicochemical parameters, and in in-vitro drug release profiles

Keywords: Olmesartan medoxomil; Direct compression method; Dispersible tablets; Crospovidone.