Abstract
FORMULATION AND EVALUATION OF DISPERSIBLE TABLETS OF OLMESARTAN MEDOXOMIL

B.Venkateswara Reddy*, N.Theja Vinod Kumar, K.Navaneetha

ABSTRACT

The purpose of this research work was to develop and evaluate dispersible tablets of Olmesartan medoxomil employing different ratios of hydrophilic polymers by direct compression method. The main objective is to avoid first pass effect and to improve bioavailability of Olmesartan medoxomil which is used in the treatment of hypertension. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. Total of 12 formulations consisting of Low substituted Hydroxy propyl cellulose, sodium starch glycolate and crospovidone in the different ratios were prepared. The prepared dispersible tablets were evaluated for in vitro drug release, moisture loss and mechanical properties. The formulations coded as F6 (Crospovidone) showed maximum release of 98.34% within 14 mins. The formulation F6 emerging to be ideal formulation for Olmesartan medoxomil. The stability studies were carried out on the most satisfactory formulation F6 and there was no significant difference in the physicochemical parameters, and in in-vitro drug release profiles

Keywords: Olmesartan medoxomil; Direct compression method; Dispersible tablets; Crospovidone.


[Full Text Article]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Tangudu Nagabhusana Rao

Download Article : Click here

News & Updation

  • EJBPS: MARCH ISSUE PUBLISHED

    MARCH 2021 Issue has been successfully launched on 1 March 2021.

  • EJBPS New Impact Factor

    Its our Pleasure to Inform you that EJBPS Impact Factor has been increased from 5.467 to 6.044, due to high quality Publication at International Level.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT