SYNTHESIS AND SCREENING FOR ANTIMICROBIAL ACTIVITY OF NOVEL BENZIMIDAZOLE CHALCONE
Muthu Bhupathi G.*, Padma Latha K., Deepthi K., Anusha O. and Chamundeswari B.
ABSTRACT
Benzimidazole ring is an important pharmaco-phor in modern drug discovery. The synthesis of novel benzimidazole derivatives remains a main focus of medicinal research as there are wide clinical applications. The benzimidazole derivatives have different pharmacological activities like Antifungal, Neuroleptic, Anti-HIV, Antihistaminic, Antiulcer, Antimicrobial, Anthelmintic, Cardio tonic & Antihypertensives. This article was summarized to know about the chemistry of different derivatives of substituted benzimidazoles along with their pharmacological activities. Novel Benzimidazole Chalcone derivatives were synthesized by using different Aromatic aldehydes like 2-Nitro Benzaldehyde, 4-Nitro Benzaldehyde, and 4-Chloro Benzaldehyde. The reaction between o-phenylenediamine and lactic acid in presence of HCl as catalyst yields first intermediate which upon oxidation with k2cr2o7 forms second intermediate and by the addition of different aromatic aldehydes, it yields 2-Nitro Benzimidazole chalcone, 4-Nitro Benzimidazole chalcone, and 4-Chloro Benzimidazole chalcone respectively. All these synthesized compounds were screened for in vitro antimicrobial activity and all of them had shown potency against both gram positive and gram negative bacteria.
Keywords: Benzimidazole Chalcone, Benzaldehyde, o-phenylenediamine, lactic acid, Antimicrobial activity.
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