Abstract
CHARACTERIZATION AND EVALUATION OF MOUTH DISSOLVING FILMS OF ATENOLOL FOR HYPERTENSION

Geethumol T. K.* and Dr. Manju Maria Mathew

ABSTRACT

The aim of this study was to develop a taste-masked mouth dissolving film (ODF) containing antihypertensive drug Atenolol .objective of study is to developing and characterizing the influence of agent such as tween 80 and polaxomer on the morphological and physicochemical characteristic of fast dissolving orodispersible films (FDOF)made up of film forming polymer Hydroxy propyl methyl cellulose. The embodiment of atenolol, in FDOF was achieved through solvent casting technique.Literature reports that faster disintegration leads to optimum drug release resulting in higher bioavailability. The present research work also attempts to correlate the effect of concentration of tween 80 and solubilizing agent on the disintegration time and drug release profile of the oral film. .literature reports give evidence that combination of HPMC and pectin as film forming polymer gives good film texture appearance and film properties .The atenolol FDOF were characterized for physical appearance, disintegration time, in vitro dissolution, etc. In the presence of solubilizing agent the morphological characters was found to be better than in its absence. Atenolol FDOF showed optimum drug content and folding endurance.Drug-excipients interaction studies performed using FTIR; showed no interaction. Surface pH was found to be neutral, indicating safety of administration. Atenolol FDOF formulated using tween 80 showed optimum results as compared to polaxomer and FDOF without solubilizing agent. Thus based on the results it can be concluded that the FDOF formulated using solubilizing agents can enhance the disintegration time and drug release profile.

Keywords: Hypertension disease; Atenolol; oral disintegrating film; polymers, tween 80.


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