European Journal of Biomedical and Pharmaceutical Sciences

ASSESSING DIETARY PATTERN V/S REFRACTORY ANEMIA ON BONE MARROW FINDINGS

Prof. (Dr.) Sharique Ahmad, Dr. Pankhudi Gupta, Dr. Noorin Zaidi, Dr. Eqbal Anwer, Prof. (Dr.) Syed Riaz Mehdi and Dr. Zeashan Haider Zaidi

ABSTRACT

World Health Organization (WHO) defined Anemia as a condition in which the number of red blood cells or their oxygen carrying capacity is insufficient to meet Physiological needs, which vary by age, sex, altitude, smoking and pregnancy status. Patients present with the complaint of Refractory Anemia (RA). Refractory Anemia is a clonal disorder originating from a totipotent stem cell or from a multipotent myeloid progenitor cell, characterized by ineffective hemopoiesis and dyserythropoiesis. It is part of the heterogeneous category of Myelodysplastic syndrome. The aetiology of megaloblastic anaemia is diverse but a common basis is impaired De-oxy Ribonucleic Acid (DNA) synthesis. Most common causes of megaloblastosis are vitamin B12 and folate deficiencies. Cobalamin metabolism and folate metabolism are intricately related, and abnormalities in these pathways may lead to the attenuated production of DNA. So, there is increased worldwide concern about the consequences of folic acid and vitamin B12 deficiencies on health, which includes megaloblastic anemia. Iron deficiency is also an important and most common cause of Iron deficiency anemia worldwide. In developed countries, the prevalence of Iron deficiency anemia has decreased rapidly during the past few decades, but in developing countries like India it is still an important cause. So, for patients presenting with Refractory Anemia on initial work up bone marrow (BM) aspirate and bone marrow biopsy were done which was further correlated with dietary habits.

Keywords: Refractory anemia, Megaloblastic anaemia, Iron deficiency anemia, Bone marrow aspiration.