European Journal of Biomedical and Pharmaceutical Sciences

PANCYTOPEN?A, SECONDARY MYELOF?BROS?S AND G?ANT CYST?C PARATHYRO?D ADENOMA

Feyzi Gokosmanoglu, Ceyhun Varim*, Hasan Ergenc, Gulsah Baycelebi, Bekir Kuru, Aysegul Atmaca, Atilla Önmez

ABSTRACT

Hyperparathyroidism may cause myelofibrosis. Primary hyperparathyroidism-induced bone marrow fibrosis has been reported in very few cases until this time. Generally, myelofibrosis has been reported in patients with hyperparathyroidism secondary to chronic renal failure. We report a 22-year-old girl who presented with a complaint of swelling in the neck to our clinical service. Primary hyperparathyroidism and pancytopenia were found in this case. There were the increased reticulin fibers in the bone marrow biopsy. The patient was operated for parathyroid adenoma. The patient’s hematological and biochemical parameters improved on the 3rd postoperative month. Therefore, we considered that the patient had myelofibrosis secondary to primary hyperparathyroidism. We report an young who presented with pancytopenia caused by myelofibrosis secondary to primary hyperparathyroidism. Hyperparathyroidism must be considered when myelofibrosis is assessed in a young person.

Keywords: Hyperparathyroidism, myelofibrosis, pancytopenia.