ANTI-CANCER ACTIVITY OF CARDIOSPERMUM HALICACABUM LINN. LEAF EXTRACTS AGAINST HUMAN BREAST CANCER CELL LINE (MCF-7)
Rajesh S., Sivakumari K.*, Ashok K. and Abitha A. R.
ABSTRACT
Objective: The objective of the research to explore the phytoconstituents presents in the aqueous, chloroform and methanol extracts of leaf of C. halicacabum. To investigate the anti-cancer potential of the all three leaf extracts of C. halicacabum against MCF-7 cell line. GC-MS study of the solvent leaf extract having higher activity. Methods: The leaves of Cardiospermum halicacabum were extracted using water, chloroform and methanol. The extracts were subjected to preliminary phytochemical analysis; the anticancer activity was evaluated by MTT assay method and GC-MS spectral analysis was carried out for the extract showing best antiproliferative activity. Results: Methanol extract gave IC50 value of 24.90 μg/ml, whereas aqueous and chloroform extracts gave IC50 value of 43.51 μg/ml and 40.34 μg/ml respectively for potential in vitro anticancer activity. The GC-MS spectra of methanol extract showed 14 peaks. Conclusion: From the results, the present study indicates the anti-cancer potential ofC. halicacabum leaves and further experiments awaits the characterization of active principle responsible for anti-cancer property.
Keywords: C. halicacabum, MCF-7 cell line and GC-MS.
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