European Journal of Biomedical and Pharmaceutical Sciences

EFFECTS OF SUB-ACUTE ADMINISTRATION OF GANODERMA LUCIDUM METHANOL EXTRACT ON SOME SERUM BIOCHEMICAL PARAMETERS IN NORMAL WISTAR RATS

Shamaki, B.U,* Sandabe, U. K., Abdulrahman, F.I., Ogbe, A. O and Gulani, I.A

ABSTRACT

Some serum biochemical parameters such as ALP, AST, ALT, Urea, Creatinine and Bilirubin were investigated in normal albino rats following daily oral administration of Ganoderma lucidum methanol extract using standard protocols. Doses of 200, 400 and 800 mg/kg were consecutively administered for 21 days, and withdrawal period of 14 days post stoppage of treatment with the extracts was used to monitor post withdrawal effects of treatment. Results from the findings showed dose dependent effect of oral administration of the extract, hile at lower doses, there were decreases in serum levels of the biochemical parameters under study, at higher doses there were significant (p<0.05) increases in the serum biochemical parameters under study. Findings from this study reveals the health benefits of extracts from this mushroom at lower doses and its possible toxic effect at high doses following prolonged administration.

Keywords: Ganoderma lucidum, methanol extract, biochemical parameters, Wistar rats.