“FORMULATION AND EVALUATION OF NANOPARTICLES CONTAINING GLIPIZIDE”
*Vishvakarma Prabhakar
ABSTRACT
Nowadays, nanotechnology has grown to be an important research field in all areas including medicinal chemistry. The size, orientation and physical properties of nanoparticles have reportedly shown to change the performance of any material. The development of new delivery systems for the controlled release of drugs is one of the most innovative fields of research in pharmaceutical sciences. Nanoparticles specially designed to release the drug in the vicinity of target sites. The aim of this study was to formulate and evaluate the Glipizide nanoparticles is to minimize the dosing frequency, taste masking and toxicity and to improve the therapeutic efficacy by formulating Glipizide nanoparticles. Glipizide is low soluble, high permeable and short half-life antidiabetic drug. Glipizide nanoparticles were formulated by ionotropic gelation method using polymer chitosan gel (1mg/ml) with seven different formulations. Nanoparticles were characterized by determining it Drug content, Fourier Transform Infra-red Spectroscopy (FT-IR) analysis, In vitro release studies, Entrapment efficiency (EE), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), Zeta Potential, X-ray diffraction, Stability studies. Drug entrapment efficacy was > 99%. The in-vitro release of nanoparticles were carried out which exhibited a sustained release of Glipizide from nanoparticles up to 24hrs. The results showed that nanoparticles can be a promising drug delivery system for sustained release of Glipizide.
Keywords: Glipizide, Calorimetry, ionotropic.
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