EFFECT OF ELAEOCARPUS GANITRUS ROXB. ON HYPERLIPIDAEMIA AND LIVER FUNCTION OF RABBIT
Pratibha K. Jain, Priyanka Sharma and Suresh C. Joshi*
ABSTRACT
In the present study 70% ethanolic crude extract of Elaeocarpus ganitrus seed has been screened for its anti-atherosclerotic and antioxidant activity in liver of cholesterol induced atherogenic rabbits. Lipid profile, lipid peroxidation level as well as histological changes in liver were investigated. The statistical analysis were carried out by using one way ANOVA followed by Tukey’s multiple comparison test. Cholesterol feeding produced a significant increase in total cholesterol, phospholipids and triglycerides in liver. It also increases lipid peroxidation as well as showed severe fatty changes in liver. E. ganitrus extract was administered at a dose level of 250 mg/kg and 500 mg/kg (p.o) daily for 60 days to cholesterol-fed rabbits rectified the disturbed lipid profile significantly and a considerable decrease in lipid peroxidation (P ≤ 0.01, ≤ 0.001) was observed. Normal histology of liver regained in cholesterol fed animals given E. ganitrus extract compared to the cholesterol fed animals. The phytochemical analysis of ethanolic extract of E. ganitrus indicated strong presence of alkaloids, flavanoids, tannins, phenols, saponins and fatty acids that may be responsible for the significant antiatherosclerotic as well as antioxidant activity. Our study exhibited that the ethanol extract of E. ganitrus seed is a potent agent and contribute remarkably in developing novel herbal medicines to improve the lives of patients suffering from cardiovascular diseases around the word.
Keywords: Atherosclerosis, Hyperlipidaemic, Phytoconstituents, Cholesterol.
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