European Journal of Biomedical and Pharmaceutical Sciences

NON INVASIVE VENTILATION (NIV) IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) WITH HYPERCAPNIC RESPIRATORY FAILURE

Manish Subedi*, Narendra Bhatta, Suman Rijal, Robin Maskey, Puru Koirala, Denis Peeyush 

ABSTRACT

Use of noninvasive ventilation in patients with COPD has found to be effective in improving outcomes at lower costs, however there is dearth of information in patient populations unique to our context. We studied the patient characteristics that could identify and predict the successful outcome of NIV. Fifty patients of COPD were enrolled in this prospective cohort study. Successful outcomes on NIV were defined as an improvement in physiological and clinical parameters allowing cessation of NIV. 68% of patients improved on NIV on regular ward basis. Patients who improved were less acidotic (pH=7.28), less hypercapnic (PaCO2= 80.56) at presentation than those who failed to improve. Absence of Cor-pulmonale, Respiratory Rate <30 and normal serum protein at presentation were additional predictors of good outcome. NIV improves outcome at lower costs and therefore it should be is considered a standard of care to be initiated in the regular medical wards.

Keywords: ventilation, COPD, NIV, Hypercapnic.