European Journal of Biomedical and Pharmaceutical Sciences

SYNTHESIS, CHARACTERIZATION AND STUDY OF MICROBIOLOGICAL ACTIVITY OF RHODIUM (III) COMPLEX WITH, 2-(5- BROMO-2- OXOINDOLIN-3-YLIDENE) HYDRAZINECARBOTHIOAMIDE

S. S. Borgave and V. D. Barhate*

ABSTRACT

A Schiff base ligand derived from 5-Bromoisatin with thiosemicarbazide, [2-(5-Bromo -2-Oxoindolin-3-ylidene) Hydrazine Carbothioamide], [HBITSC] and its complex with Rh (III) has been synthesized which was characterized by elemental analysis, molar conductance, electronic spectra, IR and NMR spectroscopy. The metal complex is coloured and solid in nature. The Schiff base ligand exhibits bidentate nature, coordination through azomethine nitrogen and thioketo sulphur to the metal ion. On the basis of electronic spectral analysis geometry of complex was proposed to be octahedral. The molar conductivity data of complex suggests its non - electrolytic nature. On the basis of above studies three ligands were suggested to be coordinated to rhodium atom by thioketo sulphur and azomethine nitrogen to form diamagnetic octahaderal complexes. The ligand and Rh (III) complex have been screened for their microbiological activity.

Keywords: Schiff base (HBITSC), Spectra, Metal Complex and Microbiological activity.