Abstract
THE FREQUENCY OF PLATELET RECEPTOR GP IIB POLYMORPHISM IN SUDANESE PATIENTS WITH CHRONIC KIDNEY FAILURE

Abeer Abd Almoneim Ata Almnan and Ibrahim K. Ibrahim*

ABSTRACT

Background Glycoprotein II b is a receptor on platelets for fibrinogen and von will brand factor and aids in the platelet activation, aggregation and adhesion to sub endothelial .Glycoprotein IIb gene found in chromosome 17 polymorphism in this gene reported to be associated with many disorder.Objective The purpose of this study was to determine the frequency of the GP IIb polymorphism in patients with chronic kidney failure in Sudan. Materials and Methods A total of 41 chronic kidney failure patients and 44 apparently healthy control subjects were evaluated to detect the frequency of GB IIb polymorphism. Platelets parameters were performed by an automated cell analyzer. The G.P IIB polymorphism was detected using RFLP-PCR. Results The wild genotype of GP IIb was found in 5 patients out of 34 and 27 of the control subjects; the hetero genotype was detected in 4 of patients and 12 of control subjects where as the homozygous genotype was detected among 32 patients and only among 5 of control and the difference was statistically significant (P.value 0.06) Table (1).In addition the GPIIb genotypes were not related to the platelet count and indices findings in study patients (Table 2). Conclusion: There was a significant association between the patients genotype and control and the homozygous genotype detected in the chronic kidney failure.

Keywords: Chronic kidney failure, Platelet, Polymorphism, G.PIIb.


[Full Text Article]   [Download Certificate]

Login





Forgot Password  |  Register

Indexing

Best Paper Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: MAY ISSUE PUBLISHED

    MAY 2024 Issue has been successfully launched on 1 MAY 2024.

  • EJBPS New Impact Factor

    EJBPS Impact Factor has been Increased to 7.482 for Year 2024.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT