European Journal of Biomedical and Pharmaceutical Sciences

THE FREQUENCY OF PLATELET RECEPTOR GP IIB POLYMORPHISM IN SUDANESE PATIENTS WITH CHRONIC KIDNEY FAILURE

Abeer Abd Almoneim Ata Almnan and Ibrahim K. Ibrahim*

ABSTRACT

Background Glycoprotein II b is a receptor on platelets for fibrinogen and von will brand factor and aids in the platelet activation, aggregation and adhesion to sub endothelial .Glycoprotein IIb gene found in chromosome 17 polymorphism in this gene reported to be associated with many disorder.Objective The purpose of this study was to determine the frequency of the GP IIb polymorphism in patients with chronic kidney failure in Sudan. Materials and Methods A total of 41 chronic kidney failure patients and 44 apparently healthy control subjects were evaluated to detect the frequency of GB IIb polymorphism. Platelets parameters were performed by an automated cell analyzer. The G.P IIB polymorphism was detected using RFLP-PCR. Results The wild genotype of GP IIb was found in 5 patients out of 34 and 27 of the control subjects; the hetero genotype was detected in 4 of patients and 12 of control subjects where as the homozygous genotype was detected among 32 patients and only among 5 of control and the difference was statistically significant (P.value 0.06) Table (1).In addition the GPIIb genotypes were not related to the platelet count and indices findings in study patients (Table 2). Conclusion: There was a significant association between the patients genotype and control and the homozygous genotype detected in the chronic kidney failure.

Keywords: Chronic kidney failure, Platelet, Polymorphism, G.PIIb.